BOSTON — John Lackey pitched two-hit ball over seven innings against his old team, David Ortiz hit a solo homer and the Boston Red Sox sent the Los Angeles Angels to their sixth straight loss, 3-1 Wednesday night.

It was Boston's third straight win over the Angels, who have lost the first six games on a 10-game road trip. It's the first time the Angels have opened May at 0-5 in team history.

Adrian Beltre homered and drove in two runs for the Red Sox. Brandon Wood hit a solo homer off Lackey.

The Red Sox can complete the four-game sweep when Daisuke Matsuzaka faces Scott Kazmir on Thursday night.