OAKLAND, Calif. — Jon Lester has been through enough emotional extremes for a lifetime over the last two years.

After surviving lymphoma and winning a World Series, after throwing a no-hitter and hearing his father's own diagnosis with cancer, the Boston left-hander seems to wish he could just get back to the mundane, everyday business of pitching — even when Lester isn't pitching as well as he would like against the surging Oakland Athletics.

Six days after he held Kansas City hitless, Lester's hopes for a second straight no-hitter ended with the first batter he faced yesterday. Jack Hannahan hit that leadoff single and later drove in two runs, and Jack Cust hit a two-run homer as the A's completed a three-game sweep of the defending World Series champions with a 6-3 victory.

Lester (3-3) allowed seven hits and four runs over five innings.

"All the positives we talked about before the season, it seemed I did the complete opposite," Lester said. "All the things we've strived to better, and it seemed like I took a step back."

Lester, who won the World Series-clinching game for Boston last fall after his remarkable comeback from cancer treatment, also revealed this weekend that his father, John, recently was diagnosed with lymphoma.

John Lester's cancer is highly treatable, the pitcher told ESPN before the Red Sox's first trip of the season to his native Seattle area.

"It hasn't," Lester said when asked if his father's condition had weighed on him. "I've always been out in the open. I just haven't told you (media). I don't want to get questions about that."

Hannahan, who reached base four times after entering the game in an 0-for-10 slump, drove in two runs in the fourth inning of Oakland's fourth consecutive win.

Rays 5, Orioles 4: Evan Longoria drove in the winning run with a double in the bottom of the ninth inning, giving host Tampa Bay a three-game sweep of Baltimore.

Rangers 2, Indians 1: Right fielder Ben Francisco misplayed a simple single into a costly error in the 10th, enabling Jarrod Saltalamacchia to score from first base with the winning run as visiting Texas beat Cleveland.

Yankees 6, Mariners 5: Jose Molina hit a two-out RBI double to cap a four-run eighth inning as host New York rallied for its fifth straight victory to earn consecutive series wins for the first time this season.

Blue Jays 3, Royals 1: Shannon Stewart drove in the go-ahead run on a fielder's choice and Dustin McGowan (3-4) won for the first time in four starts as host Toronto dealt Kansas City its seventh straight loss.

Twins 6, Tigers 1: Jason Kubel hit a tiebreaking grand slam with two outs in the eighth inning as visiting Minnesota beat Detroit.

White Sox 3, Angels 2: Carlos Quentin led off the ninth with his second homer off John Lackey and host Chicago beat Los Angeles to avoid a three-game sweep.

NATIONAL LEAGUE

Phillies 15, Astros 6: Chase Utley and Shane Victorino, a St. Anthony alum from Maui, each had three RBIs and Philadelphia finished with 16 hits in the win over host Houston.

Pirates 6, Cubs 5: Jason Bay beat the Cubs with an extra-inning single for the second day in the row, delivering a two-out line drive down the left-field line in the 11th after host Pittsburgh tied it on a dropped fly ball in the ninth.

Diamondbacks 9, Braves 3: Eric Byrnes hit his first career grand slam to knock Tom Glavine (2-2) out of the game and power visiting Arizona past Atlanta. Glavine (2-2) gave up six runs and five hits while walking six in 4 2/3 innings.

Padres 12, Reds 9: Adrian Gonzalez hit a three-run homer with two outs in the bottom of the 18th inning to give San Diego a win over Cincinnati. It was the fourth time the Padres played at least 13 innings this season. They played a 22-inning game at home against Colorado on April 17 and 18, losing 2-1. The last team to play a game of at least 22 and 17 innings in the same season was the 1989 Los Angeles Dodgers, who played two 22-inning games and a 17-inning game.

Marlins sweep GIANTS: Dan Uggla hit a bases-loaded, two-out single in the ninth inning to help host Florida beat San Francisco, 5-4, and sweep a doubleheader. Kevin Gregg (4-2) got the win for the Marlins, after working the ninth inning of the their 8-6 win in the opener for his 10th save.

Nationals 7, Brewers 6: Elijah Dukes scored on Guillermo Mota's ninth-inning wild pitch, giving host Washington a victory over Milwaukee. Jon Rauch (3-1) pitched a perfect ninth for the victory.

Dodgers 4, Cardinals 3: Andre Ethier singled home the winning run in the bottom of the 10th inning and Luis Maza hit his first big league homer, leading Los Angeles over St. Louis. Touted prospect Clayton Kershaw pitched six innings for the Dodgers in his major league debut, striking out seven.

Rockies 4, Mets 1: Seth Smith hit his first major league homer, a three-run shot off John Maine, as host Colorado beat New York.

ELSEWHERE

Red Sox: Clay Buchholz pitched four-plus innings last night in a rehab start for Triple-A Pawtucket (R.I.). On the 15-day disabled list since May 13 because of a torn nail on his middle finger, Buchholz allowed one run and three hits with three strikeouts and two walks. He threw 38 of his 63 pitches for strikes and topped out at 96 mph on the radar gun.

Pirates: Shortstop Jack Wilson will spend extra time at Double-A Altoona on a rehabilitation assignment but still plans to rejoin the Pirates in Cincinnati tomorrow. Wilson has been out of the Pittsburgh lineup with a strained left calf since April 3.

Rockies: Colorado placed left fielder Matt Holliday on the 15-day disabled list yesterday. Holliday strained his hamstring running out a groundout to third in the ninth inning of the Rockies' 9-2 loss to the New York Mets on Saturday.

Indians: Pitcher Fausto Carmona is expected to be sidelined four weeks with a strained left hip. An MRI exam revealed a moderate strain of an exterior muscle in Carmona's left hip, Lonnie Soloff, Cleveland's head athletic trainer, said yesterday.